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pentobarbital will lessen the level or outcome of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Double brexpiprazole dose about one-2 weeks if administered with a robust CYP3A4 inducer.pentobarbital will lessen the extent or outcome of acalabrutinib by influencing hepatic/intestinal enzyme